Allogene Therapeutics Announces Preclinical Publication Highlighting Superiority of Healthy Donor-Derived Allogeneic CAR T Cells Over Patient-Derived Cells in Multiple Myeloma
- Results Demonstrated Anti-BCMA CAR T Cells Derived from
Healthy Donors Had Better Immune Fitnessand Killing Activity
- Phase 1 AlloCAR T™ Trials Underway Evaluating ALLO-715 and ALLO-605 for the Treatment of Relapsed/Refractory Multiple Myeloma
- BCMA Program Clinical Update Expected by the End of 2022
“Despite the rapidly evolving treatment landscape for multiple myeloma, this hematologic cancer remains incurable. With so many patients experiencing aggressive disease progression, novel, effective and readily available therapies are needed,” said
BCMA is a validated target in multiple myeloma due to its high specificity and broad expression. In this study led by
- Healthy donors had higher T cell counts, a higher CD4/CD8 T cell ratio, and naïve/stem cell memory phenotype compared with patients with relapsed multiple myeloma.
- Anti-BCMA allogeneic CAR T cells derived from healthy donors showed efficient killing of primary multiple myeloma cells across different patient sub-groups including those with high-risk disease.
- In a subset of patient samples with low BCMA, the addition of a gamma secretase inhibitor increased the surface levels of BCMA and led to improved cytotoxic activity.
“These preclinical study results further support our approach to using allogeneic anti-BCMA CAR T cells to treat patients with multiple myeloma. As we presented at the
Manufacturing T cells from a healthy donor allows for less product variability and eliminates both the risk of manufacturing failures and the requirement for bridging therapy by enabling treatment within days. In studies on the approved autologous CAR T therapies, up to 75% of patients required bridging therapy, up to 18% of patients received therapies that were not within the required manufacturing specifications, and up to 14% of patients did not receive cells in time for treatment.
As part of Allogene’s anti-BCMA strategy, the Company has two AlloCAR T™ trials underway investigating product candidates for the treatment of multiple myeloma. The first is a Phase 1 UNIVERSAL trial that includes cohorts evaluating ALLO-715 as a monotherapy, as a consolidated dosing strategy, and in combination with SpringWorks Therapeutics’ investigational gamma secretase inhibitor, nirogacestat. ALLO-715 was granted Regenerative Medicine Advanced Therapy (RMAT) designation in
Cautionary Note on Forward-Looking Statements
This press release contains forward-looking statements for purposes of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The press release may, in some cases, use terms such as "predicts," "believes," "potential," "proposed," "continue," "estimates," "anticipates," "expects," "plans," "intends," "may," "could," "might," "will," "should" or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. Forward-looking statements include statements regarding intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things: the timing and ability to progress the UNIVERSAL and IGNITE trials, including to provide an update at year-end; the potential for promising pre-clinical data to translate to positive clinical data; clinical outcomes, which may materially change as more patient data become available; the ability to manufacture AlloCAR T™ products; and the potential benefits of AlloCAR T products. Various factors may cause differences between Allogene’s expectations and actual results as discussed in greater detail in Allogene’s filings with the SEC, including without limitation in its Form 10-K for the year ended December 31, 2021. Any forward-looking statements that are made in this press release speak only as of the date of this press release. Allogene assumes no obligation to update the forward-looking statements whether as a result of new information, future events or otherwise, after the date of this press release.
AlloCAR T™ and TurboCAR™ are trademarks of Allogene Therapeutics, Inc.
Allogene’s AlloCAR T™ programs utilize Cellectis technologies. The anti-BCMA AlloCAR T programs are licensed exclusively from Cellectis by Allogene and Allogene holds global development and commercial rights to these AlloCAR T programs.
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Chief Communications Officer
Source: Allogene Therapeutics, Inc.