Allogene Therapeutics Announces Publication of Preclinical Study Results in Molecular Therapy Highlighting Potential for ALLO-715 (an Anti-BCMA AlloCAR T™ Therapy) in Multiple Myeloma
- Anti-BCMA AlloCAR T Cells Maintained Phenotype and Sustained Potent Anti-Tumor Responses After Scaled-Up Manufacturing
- ALLO-715 Investigational New Drug Application and Phase 1 Trial Initiation Expected in 2019
“These preclinical findings validate advancing ALLO-715 produced via our proprietary manufacturing process to target BCMA, which is expressed in multiple myeloma,” said
In this study, healthy donor T cells were transduced with several candidate anti-BCMA CARs and modified using gene editing to improve CAR T cell persistence and reduce risk of graft-versus-host disease (GvHD). The safety profile of allogeneic BCMA CAR T cells was further enhanced by incorporating a CD20-based off-switch enabling effective CAR T elimination in the presence of rituximab. Allogeneic BCMA CAR T cells induced sustained antitumor responses in mice and maintained their phenotype and potency after scaled-up manufacturing.
ALLO-715 utilizes the TALEN® gene-editing technology pioneered and owned by
About Multiple Myeloma
Multiple myeloma is a type of cancer that typically affects an elderly population and is a B-cell malignancy.i Characterized by abnormalities in plasma cells, which reproduce uncontrollably in the bone marrow of people with the disease,ii multiple myeloma is incurable, and most patients relapse despite the treatments available.iii Multiple myeloma is a rare cancer, accounting for 1.8 percent of all new cancer cases, with approximately 50 percent of patients surviving five years after diagnosis.iv
Cautionary Note on Forward-Looking Statements
This press release contains forward-looking statements for purposes of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The press release may, in some cases, use terms such as "predicts," "believes," "potential," "proposed," "continue," "estimates," "anticipates," "expects," "plans," "intends," "may," "could," "might," "will," "should" or other words that convey uncertainty of future events or outcomes to identify these forward-looking statements. Forward-looking statements include statements regarding intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things: the ability and timing of filing an IND application and initiating a clinical trial for ALLO-715, the ability to manufacture ALLO-715, the ability to initiate and progress additional clinical trials of AlloCAR T therapies, and the potential benefits of AlloCAR T therapy. Various factors may cause differences between Allogene’s expectations and actual results as discussed in greater detail in Allogene’s filings with the
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i Palumbo A, Anderson K. Multiple myeloma. N Engl J Med. 2011;364(11):1046-1060.
ii Multiple myeloma - Genetics Home Reference - NIH. Retrieved from https://ghr.nlm.nih.gov/condition/multiple-myeloma#
iii Sonneveld P, Broijl A. Treatment of relapsed and refractory multiple myeloma. Haematologica. 2016;101(4):396-406.
iv U.S. SEER Database.
Source: Allogene Therapeutics, Inc.